One of the fundamental challenges in Islamic societies is the emergence of sedition, which threatens their security and social cohesion by creating an atmosphere of doubt and mixing truth with falsehood, and leads to the distortion of the religious and social foundations of the society's individuals. Given the importance of this issue, in order to achieve a society immune to sedition, it seems essential to recognize the components that provide immunity in dealing with them. The infallible Imams, especially Imam Ali and Imam Reza, have repeatedly described seditions and their consequences and have expressed effective solutions for dealing with seditions. This research aims to identify the immunity-giving components in the lives of these two Imams and to design a practical model for dealing with contemporary seditions. For this purpose, using a descriptive-analytical method and relying on Quranic verses and reliable narrational sources, the speeches of Amir al-Mu'minin and Imam Reza were examined in terms of immunity-giving components And a practical model for dealing with contemporary seditions is presented. The findings indicate that, in addition to common components such as adherence to the Quran, piety, insight, and patience, Imam Ali's life is focused on principles such as the implementation of justice, unity, and Imam Reza's life is focused on debates, educating a scientific generation, and taqiyyah. The research achievement is the extraction of a "sedition cycle management model" in four stages: prevention, detection, confrontation, and repair, which is presented as a three-level operational framework (individual, social, structural) for building immunity against contemporary seditions.This model can serve as a roadmap for cultural and social institutions in intelligently confronting the seditions of the present era.